Uses of Isothermal Microcalorimetry in Urology In this TA Instruments sponsored webinar, Dr. Olivier Braissant discusses the process of detecting and monitoring biological processes with isothermal calorimetry. This has been shown to be an accurate analytical technique and is proportional to the rate at which a given chemical or physical process takes place.
Plasma Protein Calorimetry For Clinical Diagnostics In this TA Instruments sponsored webinar, Dr. Nichola Garbett discusses the emerging technique of using high sensitivity DSC analysis of blood plasma for plasma proteome research, and as a clinical diagnostic tool.
Measuring Thermodynamic Parameters in the Drug Development Process Is there a benefit to measuring thermodynamic parameters in the drug development process? In this TA Instruments Webinar, Dr. John E. Ladbury discusses Thermodynamic Parameterization of protein-ligand interaction, not only provides quantification of the affinity of an interaction, but also the underlying changes in enthalpy and entropy.…
Thermodynamic Rules To Achieve High Binding Affinity & Selectivity High affinity and selectivity are two essential properties of drug molecules. Since the binding affinity is determined by the sum of enthalpic and entropic contributions, extremely high affinity necessitates optimization of both contributions to binding. An efficient approach requires accurate prediction of the contributions of specific…