Overview Differential Scanning Calorimetry (DSC) is typically used during biopharmaceutical development to characterize a biomolecule through its thermal stability and unfolding profile. Here we demonstrate the suitability of DSC for studies of opaque solutions and slurries. Because of its universal indicator, heat, the technique can be applied to samples with magnetic or polystyrene beads,…
Overview It is now well established that the calendar life and cycle life of Li and Li-ion cells and batteries is highly dependent upon the secondary reactions that occur between the electrodes and the cell electrolyte. These reactions are often referred to as parasitic reactions, as they generally result in the loss of…
Overview Thermogravimetric Analysis, or TGA, is a powerful analytical tool for measuring changes in a sample’s mass as its environmental temperature shifts. When coupled with other instrumental techniques such as mass spectrometers and infrared spectrometers, chemical analysis of the evolved gases is achieved. These hyphenated techniques have a long history in thermal analysis.…
Overview: Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and researchers move to develop new candidates. In this webinar, Dr. Shawn Owen discusses advanced characterization techniques to assess antibody-drug conjugates (ADCs) and antibody-fusion proteins. For ADCs, the level of payload and site of conjugation are determined…
Benefits of Microscopy for Interpretation of DSC Thermograms DSC thermograms can be complicated and difficult to interpret, sometimes requiring multiple experiments in order to better understand a thermal event. The NEW Microscope Accessory for the Discovery DSC helps to eliminate these issues by allowing the user to easily view the sample while the DSC experiment…
DSC Characterization of Crystalline Structure in Foods and Pharmaceuticals Differential Scanning Calorimetry (DSC) is an analytical technique frequently used to detect and quantify crystalline content of pharmaceuticals, foods, polymers, and many other materials. Appearing as an endothermic peak during heating in a DSC experiment, the temperature and area of the peak can be used to…
Isothermal Microcalorimetry in Pharmaceutical Science This webinar will review the microcalorimetric techniques that are most commonly used within pharmaceutical science, including stability and compatibility tests, determination of small amounts of amorphic content, and characterizing polymorphism. A microcalorimeter can quantify the amount and rate of heat release from chemical processes associated with stability and shelf…
Interfacial Rheology: Fundamental Overview and Applications Overview Interfacial rheology dominates the behavior of many complex fluid systems. Whether the system is characterized by a fluid-fluid interface or fluid-air interface, these characteristics influence the behavior of biological systems, oil recovery, personal care products, food and more. Learn the basic forces that drive interfacial dynamics and…
In this webinar, Dr. Colette Quinn discusses the use of differential scanning calorimetry (DSC) in protein stability characterization differences resulting from preparation changes of identical systems. Protein stability, particularly antibodies, can be determined via DSC without restrictions on buffers, excipients, and detergents. DSC, a native assay, works equally well for modified proteins such as antibody…
Designing New Materials for Additive Manufacturing: Vat Photopolymerization Overview 3D printing, or additive manufacturing (AM), provides opportunities to create previously unattainable geometric objects through layer-by-layer fabrication. Novel macromolecular structures and synthetic methods coupled with unique printing methods lead to 3D part generation with micron-scale resolution and tunable to emerging technologies. By tuning polymer structure, printing…
Long Term Stability Analysis of Monoclonal Antibodies Overview Characterization of biopharmaceuticals during all development phases is critical to the candidate selection process and the ongoing production of the active material. Some recent efforts to achieve patient self-administration has required high API concentrations (100-300 mg/mL). Development concerns for the high concentration formulations are denaturation, aggregation…
Stability Testing of Energetic Materials by Isothermal Microcalorimetry Overview This webinar introduces the use of isothermal microcalorimetry for stability measurement of energetic materials. Energetic materials refer to materials, chemicals and substances which exhibit a risk for self-decomposition associated with self-heating ultimately resulting in run-way reactions. Such materials include propellants, percarbonates and peroxides, and these…