Measuring Thermodynamic Parameters in the Drug Development Process Is there a benefit to measuring thermodynamic parameters in the drug development process? In this TA Instruments Webinar, Dr. John E. Ladbury discusses Thermodynamic Parameterization of protein-ligand interaction, not only provides quantification of the affinity of an interaction, but also the underlying changes in enthalpy and entropy.…
Gerald Fuller – Interfacial Rheology OVERVIEW Interfacial rheology dominates the behavior of many complex fluid systems. Whether the system is characterized by a fluid-fluid interface or fluid-air interface, these characteristics influence the behavior of biological systems, oil recovery, personal care products, food and more. Learn about the basic forces that drive interfacial dynamics and stability,…
Thermodynamic Rules To Achieve High Binding Affinity & Selectivity High affinity and selectivity are two essential properties of drug molecules. Since the binding affinity is determined by the sum of enthalpic and entropic contributions, extremely high affinity necessitates optimization of both contributions to binding. An efficient approach requires accurate prediction of the contributions of specific…
OVERVIEW Large amplitude oscillatory shear (LAOS) is used increasingly as a tool to measure the nonlinear viscoelastic responses of soft solids and complex fluids. For many material systems the common practice of reporting only “viscoelastic moduli” (typically corresponding to the first harmonic Fourier coefficients G’1(w), G”1(w)) is insufficient and/or misleading in describing the nonlinear phenomena.…
Jan Vermant – Orthogonal Superposition Rheology OVERVIEW Superposition flows in rheology are powerful methods to understand non-linear and anisotropic viscoelasticity. Parallel Superposition experiments have been historically simple to perform, but are difficult to understand and do not provide all of the desired information. Recent developments have made Orthogonal Superposition more simple to perform, allowing…
Professor Chris Macosko – Analyzing Molecular Weight Distribution w/ Rheology In this TA Instruments Webinar, Professor Chris Macosko discusses analyzing molecular weight distribution and blend morphology using rheology. Rheology is a powerful tool for analyzing polymer blends. This seminar will begin with the simplest case: molten blends of two different molecular weight homopolymers.We will…