DSC Characterization of Crystalline Structure in Foods and Pharmaceuticals: Apparent Melting
Part 2
Overview
This webinar on “Apparent Melting” is part two of a three-part series on use of Differential Scanning Calorimetry to characterize crystalline structure of foods and pharmaceuticals. Although apparent melting looks like true/thermodynamic melting and causes a loss of crystalline structure, it creates significant limitations for analysis and reporting of typical properties such as melting point and heat of fusion. In addition, apparent melting always causes chemical change which affects measurement of other important properties such as purity, identification of polymorphs and even glass transitions of melted materials. This webinar will compare both theory and results for thermodynamic and apparent melting and explain why it is important to distinguish between them when interpreting results from DSC.
Part three of the series will follow at a later date and show how the approach of apparent melting can assist with detection and analysis of drug-excipient incompatibility in mixtures and formulations. The approach of apparent melting provides an opportunity to create a rapid screening tool with significant advantages over traditional methods that require long-term oven aging and chemical analysis.
Watch Part 1: Use of Calorimetry (DSC) to Measure Crystalline Structure in Pharmaceuticals
About the Speaker
Len Thomas joined the DuPont thermal analysis business in 1974 after spending 6 years as a research chemist in DuPont Photo Products. He is a Fellow in the North American Thermal Analysis Society (NATAS) and has taught many of their short courses.
Len was part of the management team that acquired the thermal business from DuPont in 1990 to create TA Instruments. Prior to becoming President of TA Instruments from 1996 to 2000, Len held positions in Sales, Sales Management, Marketing, and Applications Development. Len started his consulting business, DSC Solutions LLC, in 2005 and continues to support many TA Instruments customers.
