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Thermodynamic Rules To Achieve High Binding Affinity & Selectivity

Thermodynamic Rules To Achieve High Binding Affinity & Selectivity High affinity and selectivity are two essential properties of drug molecules. Since the binding affinity is determined by the sum of enthalpic and entropic contributions, extremely high affinity necessitates optimization of both contributions to binding. An efficient approach requires accurate prediction of the contributions of specific…

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