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Aug192024

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Why DSC Testing is a Critical Step in Developing Biosimilar Drugs

Biopharmaceuticals, Microcalorimetry

Biologic therapies derived from living organisms have revolutionized the treatment of complex diseases, yet their high development costs are often passed onto patients. Biosimilar drugs offer a promising solution to reduce costs while maintaining therapeutic efficacy. Unlike generic drugs, biosimilars cannot be exact replicas of their reference biologics due to their complex structures, necessitating rigorous testing and regulatory approval.

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Sep232024

What Your Material Specification Sheet Doesn’t Tell You

Mechanical Testing, Polymers, Thermal Analysis

When it comes to selecting materials for your next innovative product, the material specification sheet is likely the first place that you will turn. This document provides core properties measured by the manufacturer and serves as an essential tool for supplier verification and new product development. However, while these sheets are reliable and provide a standard method for comparison, they often fail to tell the whole story.

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Nov42024

What is Thermogravimetric Analysis?

Composites, Fine & Specialty Chemicals, Food Products, Pharmaceuticals, Polymers, Thermal Analysis

A testament to the march of scientific inquiry, thermogravimetry emerged through the integration of three individual inventions in the 19th and 20th centuries: the electric furnace, the thermocouple, and the microbalance. As a cornerstone of material science, chemistry, and various other industries, thermogravimetric analysis (TGA) has since developed in leaps and bounds. Today, TA Instruments are leading the way in TGA, and we welcome you to join us as we explore the workings and applications of this groundbreaking technique.

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Mar142022

What is Isothermal Titration Calorimetry (ITC)?

Biopharmaceuticals, Microcalorimetry, Thermal Analysis

Isothermal Titration Calorimetry (ITC) is an experimental method used to measure the amount of heat released or consumed during a bimolecular chemical reaction. Chemical reactions can be either exothermic or endothermic, depending on the relative energetic stabilities of the reactants. Isothermal titration calorimetry can be used to quantify the magnitude of the heat change during the reaction.

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Nov52024

What is Isothermal Microcalorimetry (IMC)?

Batteries & Battery Materials, Blog Applications, Blog Techniques, Microcalorimetry

Isothermal Microcalorimetry (IMC) is a highly sensitive analytical technique that measures the heat flow in chemical and physical processes under constant temperature. IMC enables the precise detection of thermal reactions, including phase transitions, binding events, and metabolic processes, making it invaluable in fields such as pharmaceuticals, materials science, and battery research.

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Feb72022

What is Differential Scanning Calorimetry?

Pharmaceuticals, Polymers, Thermal Analysis

Differential scanning calorimetry is an analytical technique used to measure the amount of heat released or absorbed by a sample during heating or cooling over a range of temperature. As well as being used to characterize the thermal properties of a material, a differential scanning calorimeter is used to determine the temperature at which particular phase transitions occur, including glass transition temperature, fusion and crystallization events.

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Feb142022

What does COP 26 mean for the batteries industry?

Batteries & Battery Materials, Electronic Materials & Products, Rheology, Thermal Analysis

In autumn of 2021, the 26th UN Climate Change Conference of the Parties (COP 26) met in Glasgow to work out agreements to curb greenhouse gas emissions and prevent additional climate change. COP 26 built upon the Paris Agreement to limit global warming below 2-degrees Celsius by achieving net zero carbon dioxide (CO2) emissions. These two agreements will shape how governments and industries work together to reduce climate change over the next decade.

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Jan312022

What are Rheometry and Rheology?

Food Products, Paints, Inks, & Coatings, Polymers, Rheology

Whether researchers are optimizing the texture of yogurt or studying adhesives’ curing, rheometry helps us understand materials and predict their behavior. Rheometry measures the amount of deformation a material or liquid undergoes when a force is applied. The combination of stress, strain and shear behavior forms the basis of rheology, the science of the deformation of materials.

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Sep302024

Viscometer vs Rheometer: Discover Why a Rheometer Offers More Than Just Viscosity Measurement

Polymers, Rheology

If you’re working with materials that can be flowed, for example within pharmaceutical, food, cosmetics, or petrochemical industries, it’s likely that there is a viscometer in the laboratory that is the go-to instrument for formulation testing or QA purposes. However, does this viscometer give you the whole picture and fully meet all your needs?

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May282024

Syringe and needle with glass medical ampoule vials for injection. Medicine is dry white drug penicillin powder or liquid with of aqueous solution in ampulla

Unlocking Stability: The Crucial Role of Thermal Analysis in Lyophilization Temperature Optimization

Biopharmaceuticals, Microcalorimetry

The method of drug delivery significantly influences the final stages of the manufacturing process. Currently, lyophilization—a widely adopted technique—enables drug developers to stabilize formulations and therapeutic molecules using a validated commercial approach. In this process, precise control of pressure and temperature within a lyophilizer facilitates the removal of liquids from formulations containing thermally sensitive or hydrolytically unstable active pharmaceutical ingredients or formulation components.

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