Biophysical Characterization of Antibody Drug Conjugates Using DSC In this webinar, Dr. Colette Quinn discusses the use of differential scanning calorimetry (DSC) in protein stability characterization differences resulting from preparation changes of identical systems. Protein stability, particularly antibodies, can be determined via DSC without restrictions on buffers, excipients, and detergents. DSC, a native…
DetailsDesigning New Materials for Additive Manufacturing: Vat Photopolymerization Overview 3D printing, or additive manufacturing (AM), provides opportunities to create previously unattainable geometric objects through layer-by-layer fabrication. Novel macromolecular structures and synthetic methods coupled with unique printing methods lead to 3D part generation with micron-scale resolution and tunable to emerging technologies. By tuning polymer structure, printing…
DetailsLong Term Stability Analysis of Monoclonal Antibodies Overview Characterization of biopharmaceuticals during all development phases is critical to the candidate selection process and the ongoing production of the active material. Some recent efforts to achieve patient self-administration has required high API concentrations (100-300 mg/mL). Development concerns for the high concentration formulations are denaturation, aggregation…
DetailsStability Testing of Energetic Materials by Isothermal Microcalorimetry Overview This webinar introduces the use of isothermal microcalorimetry for stability measurement of energetic materials. Energetic materials refer to materials, chemicals and substances which exhibit a risk for self-decomposition associated with self-heating ultimately resulting in run-way reactions. Such materials include propellants, percarbonates and peroxides, and these…
DetailsIntroducing the New TAM Air Isothermal Calorimeter This webinar introduces the all-new TAM Air Isothermal Calorimeter. Delivering the performance, reliability, and ease-of-use that is the hallmark of TA Instruments products, the new TAM Air maintains its leadership position as the instrument of choice for cement and concrete hydration analysis using ASTM C1702 and C1679, as…
DetailsChris Yakacki: Characterization of Active Shape-Memory Polymers The field of stimuli-sensitive polymers has grown rapidly over the past decade. Actively-moving polymers have gained attention and have been proposed for use in applications from shape-changing biomedical devices to morphing structures. This webinar covers the basics of characterizing shape-memory polymers using thermo-mechanical equipment, such as the Q800…
DetailsAn Introduction To High Pressure Rheology High pressure rheology explores phenomena that are not accessible at ambient laboratory conditions. Three of the advantages of using a pressure rheometer cell include a controlled environment for volatile fluids, saturating fluids with soluble constituents, and exploring new phase space using a combination of temperature and pressure.
DetailsRubber Process Analyzer (RPA) for Elastomer and Compound Development and Quality Control The Rubber Process Analyzer (RPA) is an important tool for developing – and controlling the reliable manufacture of – elastomers and compounds. The RPA can provide far more information than traditional rubber testing methods such as the MDR or Mooney viscometer. In this…
DetailsDile Holton, Ph.D.: Characterization of Drug Binding Activity and Biopharmaceutical Stability This webinar is focused on enthalpy screening, a new and recently published ITC technique that is showing promise for rapidly and accurately characterizing the binding enthalpy of new drugs or biotherapeutics. Rapid and accurate characterization of biopharmaceuticals is essential for the early selection of…
DetailsRandy H. Ewoldt: Experimental Challenges of Shear Rheology, How to Avoid Bad Data How do you know when to trust your rheology data? How do you avoid bad data? Is there a checklist? Can you co-plot quantitative experimental boundaries against measured data? This presentation will discuss techniques for identifying and minimizing experimental errors and for…
DetailsTroy Nickel: An Introduction to Fatigue Testing Material or structural failures are typically the result of two types of loading modes: a single (static) load that results in failure or a repeated (cyclic) load that causes the material or structure to fatigue over time. When designing materials or structures it is important to understand which…
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